Yes, if you want to configure WordPress Multisite with different domains and certificate files you will need to edit the /opt/bitnami/apps/wordpress/conf/httpd-vhosts.conf file and then include that file in the /opt/bitnami/apache2/conf/bitnami/bitnami-apps-vhosts.conf one
Include "/opt/bitnami/apps/wordpress/conf/httpd-vhosts.conf "
You will also need to restart Apache after that
sudo /opt/bitnami/ctlscript.sh restart apache
If you have any questions about the configuration, we have a Support Tool that will gather relevant information for us to review. Could you please download and execute it on the machine where the stack is running by following the steps described in the guide below?
How to Run the Bitnami Support Tool
Please note that you need to paste the code outputted by the tool in your reply.