Do you mean to be able to run "python" commands, etc? if you want to access to the Virtual Machine from your machine itself, I would recommend to log in through SSH and run any Django command.
Virtual Machines do not have enabled the SSH port by default but it is easy to enable it:
Another option is to use the Bitnami Native Installers for your platform. They are self-contained and independent of your system so you can install them without any risk.
Could you post if that replies your question or if you are thinking on a different configuration?